Drug interactions
Estazolam + Oxazepam
Severity: Moderate
Estazolam and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two benzodiazepines together provides duplicate therapy and increases sedation, psychomotor impairment, confusion and the risk of respiratory depression. The risk is greater in older adults and those with respiratory disease.
What this interaction means in plain words
Estazolam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive positive allosteric modulation of GABA-A receptors by two benzodiazepines.
What to do
Avoid routine concurrent use of two benzodiazepines and consolidate to a single agent where possible. If a transition is underway, taper one drug gradually and monitor sedation and breathing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Estazolam with Oxazepam?
MediHelp rates the interaction as moderate. Estazolam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking two benzodiazepines together provides duplicate therapy and increases sedation, psychomotor impairment, confusion and the risk of respiratory depression. The risk is greater in older adults and those with respiratory disease.
How serious is the interaction between Estazolam and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two benzodiazepines and consolidate to a single agent where possible. If a transition is underway, taper one drug gradually and monitor sedation and breathing.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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