Drug interactions
Estradiol vaginal + Ketoconazole
Severity: Minor
Estradiol vaginal and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may increase systemic estradiol levels, though absorption from vaginal products is limited. Estrogenic adverse effects could become more likely.
What this interaction means in plain words
Estradiol vaginal and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ketoconazole inhibits CYP3A4-mediated estradiol metabolism.
What to do
No routine change is needed. Watch for estrogenic effects such as breast tenderness or bleeding and lower the estradiol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Estradiol vaginal with Ketoconazole?
MediHelp rates the interaction as minor. Estradiol vaginal and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may increase systemic estradiol levels, though absorption from vaginal products is limited. Estrogenic adverse effects could become more likely.
How serious is the interaction between Estradiol vaginal and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for estrogenic effects such as breast tenderness or bleeding and lower the estradiol dose if they occur.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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