Drug interactions
Estrogens conjugated synthetic + Ketoconazole
Severity: Moderate
Estrogens conjugated synthetic and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise estrogen exposure, increasing estrogen-related effects such as breast tenderness, nausea, edema and breakthrough bleeding.
What this interaction means in plain words
Estrogens conjugated synthetic and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits CYP3A4 metabolism of estrogens and may inhibit P-glycoprotein.
What to do
Monitor for estrogenic adverse effects and reduce the estrogen dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Estrogens conjugated synthetic with Ketoconazole?
MediHelp rates the interaction as moderate. Estrogens conjugated synthetic and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may raise estrogen exposure, increasing estrogen-related effects such as breast tenderness, nausea, edema and breakthrough bleeding.
How serious is the interaction between Estrogens conjugated synthetic and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and reduce the estrogen dose if they occur.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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