Drug interactions
Estropipate + Nilotinib
Severity: Minor
Estropipate and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-glycoprotein, which may modestly increase exposure to estropipate. This could heighten estrogen-related adverse effects. The effect is likely small in most patients.
What this interaction means in plain words
Estropipate and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nilotinib weakly inhibits CYP3A4 and P-glycoprotein, reducing estrogen metabolism and efflux.
What to do
Monitor for estrogen excess symptoms such as breast tenderness, fluid retention or abnormal bleeding. Lower the estropipate dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Estropipate with Nilotinib?
MediHelp rates the interaction as minor. Estropipate and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP3A4 and P-glycoprotein, which may modestly increase exposure to estropipate. This could heighten estrogen-related adverse effects. The effect is likely small in most patients.
How serious is the interaction between Estropipate and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess symptoms such as breast tenderness, fluid retention or abnormal bleeding. Lower the estropipate dose if these occur.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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