Drug interactions
Ethanol + Nateglinide
Severity: Moderate
Ethanol and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol can enhance the hypoglycemic effect of nateglinide, particularly when taken without food, and may disturb glycemic control. No disulfiram-like reaction is established.
What this interaction means in plain words
Ethanol and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alcohol suppresses hepatic gluconeogenesis, adding to glucose-dependent insulin secretion from nateglinide.
What to do
Advise limiting alcohol and never drinking without food; monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Ethanol with Nateglinide?
MediHelp rates the interaction as moderate. Ethanol and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol can enhance the hypoglycemic effect of nateglinide, particularly when taken without food, and may disturb glycemic control. No disulfiram-like reaction is established.
How serious is the interaction between Ethanol and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting alcohol and never drinking without food; monitor blood glucose.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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