Drug interactions
Ethanol + Repaglinide
Severity: Moderate
Ethanol and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol can potentiate the hypoglycemic effect of repaglinide, particularly when drinking occurs without food. It may also disrupt glycemic control. There is no established disulfiram-like reaction with this drug.
What this interaction means in plain words
Ethanol and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alcohol suppresses hepatic gluconeogenesis, adding to insulin secretion stimulated by repaglinide.
What to do
Advise limiting alcohol and never drinking without food; monitor blood glucose and teach hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Ethanol with Repaglinide?
MediHelp rates the interaction as moderate. Ethanol and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol can potentiate the hypoglycemic effect of repaglinide, particularly when drinking occurs without food. It may also disrupt glycemic control. There is no established disulfiram-like reaction with this drug.
How serious is the interaction between Ethanol and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting alcohol and never drinking without food; monitor blood glucose and teach hypoglycemia recognition.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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