Drug interactions
Ethinyl estradiol-levonorgestrel + Larotrectinib
Severity: Minor
Ethinyl estradiol-levonorgestrel and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor, so it could slightly raise levonorgestrel exposure. No meaningful clinical effect is expected. Larotrectinib is teratogenic, so contraceptive reliability remains important.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reduces metabolism of levonorgestrel.
What to do
No dose change is usually needed. Monitor for progestogenic adverse effects and recommend reliable contraception during larotrectinib treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Larotrectinib?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor, so it could slightly raise levonorgestrel exposure. No meaningful clinical effect is expected. Larotrectinib is teratogenic, so contraceptive reliability remains important.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for progestogenic adverse effects and recommend reliable contraception during larotrectinib treatment.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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