Drug interactions
Ethinyl estradiol-levonorgestrel + Mavacamten
Severity: Major
Ethinyl estradiol-levonorgestrel and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten may induce CYP3A4 and lower levonorgestrel and ethinyl estradiol exposure, risking contraceptive failure or breakthrough bleeding. Pregnancy prevention is important with this drug.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Mavacamten belongs to Cardiovascular.
Why it happens
Induction of CYP3A4-mediated metabolism of the contraceptive hormones.
What to do
Use a method unaffected by enzyme induction, such as an intrauterine system, or add a barrier method during therapy and for several months after the last dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Mavacamten?
MediHelp rates the interaction as major. Ethinyl estradiol-levonorgestrel and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten may induce CYP3A4 and lower levonorgestrel and ethinyl estradiol exposure, risking contraceptive failure or breakthrough bleeding. Pregnancy prevention is important with this drug.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a method unaffected by enzyme induction, such as an intrauterine system, or add a barrier method during therapy and for several months after the last dose.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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