Drug interactions
Ethinyl estradiol-levonorgestrel + Minocycline
Severity: Minor
Ethinyl estradiol-levonorgestrel and Minocycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline-class antibiotics were hypothesized to reduce contraceptive efficacy by disrupting gut flora. Controlled data do not show a consistent fall in hormone levels or increased ovulation, so the risk is considered very low.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Minocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Minocycline belongs to Anti Bacterial.
Why it happens
Theoretical reduction of enterohepatic recirculation of ethinyl estradiol through altered gut flora.
What to do
No routine action is needed; ensure consistent pill use and advise backup contraception if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Minocycline?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Minocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline-class antibiotics were hypothesized to reduce contraceptive efficacy by disrupting gut flora. Controlled data do not show a consistent fall in hormone levels or increased ovulation, so the risk is considered very low.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Minocycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; ensure consistent pill use and advise backup contraception if vomiting or severe diarrhea occurs.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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