Drug interactions
Ethinyl estradiol-levonorgestrel + Nilotinib
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor that might raise nilotinib levels. Nilotinib prolongs the QT interval in a concentration-related manner, so higher exposure could be important. The effect of the contraceptive is likely small, but nilotinib's narrow safety margin justifies attention.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol may reduce nilotinib clearance.
What to do
Obtain a baseline ECG and monitor QT interval and electrolytes periodically. Consider a non-hormonal or alternative contraceptive method, as nilotinib therapy needs effective contraception anyway.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Nilotinib?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol is a weak CYP3A4 inhibitor that might raise nilotinib levels. Nilotinib prolongs the QT interval in a concentration-related manner, so higher exposure could be important. The effect of the contraceptive is likely small, but nilotinib's narrow safety margin justifies attention.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QT interval and electrolytes periodically. Consider a non-hormonal or alternative contraceptive method, as nilotinib therapy needs effective contraception anyway.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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