Drug interactions
Ethinyl estradiol-levonorgestrel + Rasagiline
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is cleared mainly by CYP1A2, and inhibitors increase its exposure. Ethinyl estradiol is a weak CYP1A2 inhibitor, so rasagiline levels may rise modestly, increasing the likelihood of dose-related adverse effects.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Rasagiline belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2 by ethinyl estradiol reduces rasagiline metabolism.
What to do
Monitor for rasagiline adverse effects such as orthostatic hypotension, dyskinesia and nausea. Rasagiline labeling recommends 0.5 mg daily with CYP1A2 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Rasagiline?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is cleared mainly by CYP1A2, and inhibitors increase its exposure. Ethinyl estradiol is a weak CYP1A2 inhibitor, so rasagiline levels may rise modestly, increasing the likelihood of dose-related adverse effects.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rasagiline adverse effects such as orthostatic hypotension, dyskinesia and nausea. Rasagiline labeling recommends 0.5 mg daily with CYP1A2 inhibitors.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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