Drug interactions
Ethinyl estradiol-levonorgestrel + Somatrogon
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, which may blunt the effect of somatrogon. Patients may need higher growth hormone doses.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Oral estrogen's first-pass hepatic effect antagonizes growth hormone signaling and lowers IGF-1 generation.
What to do
Monitor IGF-1 levels and clinical response, and titrate the somatrogon dose accordingly. Consider a non-oral estrogen route if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Somatrogon?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, which may blunt the effect of somatrogon. Patients may need higher growth hormone doses.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor IGF-1 levels and clinical response, and titrate the somatrogon dose accordingly. Consider a non-oral estrogen route if appropriate.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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