Drug interactions
Ethinyl estradiol-norgestimate + Nilotinib
Severity: Moderate
Ethinyl estradiol-norgestimate and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol may slightly increase nilotinib exposure through CYP3A4 inhibition. Nilotinib prolongs the QT interval, so higher levels could raise arrhythmia risk. Nilotinib may also affect contraceptive hormone levels, and reliable contraception is essential during therapy.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol increasing nilotinib exposure.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during therapy. Discuss non-hormonal or additional contraception given pregnancy risk with nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Nilotinib?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol may slightly increase nilotinib exposure through CYP3A4 inhibition. Nilotinib prolongs the QT interval, so higher levels could raise arrhythmia risk. Nilotinib may also affect contraceptive hormone levels, and reliable contraception is essential during therapy.
How serious is the interaction between Ethinyl estradiol-norgestimate and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during therapy. Discuss non-hormonal or additional contraception given pregnancy risk with nilotinib.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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