Drug interactions
Ethinyl estradiol-norgestimate + Rasagiline
Severity: Moderate
Ethinyl estradiol-norgestimate and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is cleared mainly by CYP1A2, and ethinyl estradiol may weakly inhibit this enzyme. Rasagiline exposure may increase, with potential for more dopaminergic or MAO-B-related adverse effects.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Rasagiline belongs to Central Nervous System.
Why it happens
CYP1A2 inhibition by ethinyl estradiol reduces rasagiline metabolism.
What to do
Monitor for adverse effects and keep the rasagiline dose at no more than 0.5 mg daily, as labeling advises for CYP1A2 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Rasagiline?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is cleared mainly by CYP1A2, and ethinyl estradiol may weakly inhibit this enzyme. Rasagiline exposure may increase, with potential for more dopaminergic or MAO-B-related adverse effects.
How serious is the interaction between Ethinyl estradiol-norgestimate and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and keep the rasagiline dose at no more than 0.5 mg daily, as labeling advises for CYP1A2 inhibitors.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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