Drug interactions
Ethinyl estradiol-norgestimate + Ropinirole
Severity: Moderate
Ethinyl estradiol-norgestimate and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ropinirole is metabolised mainly by CYP1A2, and estrogens reduce its clearance. Ropinirole levels can rise, leading to more nausea, somnolence or orthostatic hypotension.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Ropinirole belongs to Central Nervous System.
Why it happens
CYP1A2 inhibition by ethinyl estradiol decreases ropinirole clearance.
What to do
Adjust the ropinirole dose according to response and tolerability when estrogen therapy is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Ropinirole?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ropinirole is metabolised mainly by CYP1A2, and estrogens reduce its clearance. Ropinirole levels can rise, leading to more nausea, somnolence or orthostatic hypotension.
How serious is the interaction between Ethinyl estradiol-norgestimate and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust the ropinirole dose according to response and tolerability when estrogen therapy is started or stopped.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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