Drug interactions
Ethinyl estradiol-norgestimate + Somapacitan
Severity: Moderate
Ethinyl estradiol-norgestimate and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens can blunt the IGF-1 response to growth hormone, so patients may need higher somapacitan doses. This is most relevant in women with growth hormone deficiency.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Oral estrogen reduces hepatic IGF-1 production in response to growth hormone through first-pass hepatic effects.
What to do
Monitor IGF-1 levels and clinical response and titrate the somapacitan dose. Consider a non-oral estrogen route where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Somapacitan?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral estrogens can blunt the IGF-1 response to growth hormone, so patients may need higher somapacitan doses. This is most relevant in women with growth hormone deficiency.
How serious is the interaction between Ethinyl estradiol-norgestimate and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor IGF-1 levels and clinical response and titrate the somapacitan dose. Consider a non-oral estrogen route where appropriate.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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