Drug interactions
Ethinylestradiol + Frovatriptan
Severity: Minor
Ethinylestradiol and Frovatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is a weak CYP1A2 inhibitor and may slightly raise frovatriptan exposure. Studies of frovatriptan with oral contraceptives showed no clinically important effect.
What this interaction means in plain words
Ethinylestradiol and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP1A2 by ethinylestradiol may reduce frovatriptan clearance.
What to do
No dose adjustment is required. Be aware of possible mild increases in triptan adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Frovatriptan?
MediHelp rates the interaction as minor. Ethinylestradiol and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol is a weak CYP1A2 inhibitor and may slightly raise frovatriptan exposure. Studies of frovatriptan with oral contraceptives showed no clinically important effect.
How serious is the interaction between Ethinylestradiol and Frovatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Be aware of possible mild increases in triptan adverse effects.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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