Drug interactions
Ethinylestradiol + Insulin degludec-liraglutide
Severity: Moderate
Ethinylestradiol and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol, especially in combined oral contraceptives, can reduce glucose tolerance and insulin sensitivity. Glycemic control on insulin degludec/liraglutide may worsen, particularly after initiation of the estrogen.
What this interaction means in plain words
Ethinylestradiol and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through estrogen and progestin effects on glucose tolerance and insulin resistance.
What to do
Monitor glucose when starting or stopping ethinylestradiol products. Adjust the insulin degludec/liraglutide dose according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Ethinylestradiol with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Ethinylestradiol and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinylestradiol, especially in combined oral contraceptives, can reduce glucose tolerance and insulin sensitivity. Glycemic control on insulin degludec/liraglutide may worsen, particularly after initiation of the estrogen.
How serious is the interaction between Ethinylestradiol and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping ethinylestradiol products. Adjust the insulin degludec/liraglutide dose according to readings.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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