Drug interactions
Ethinylestradiol + Insulin glargine-lixisenatide
Severity: Moderate
Ethinylestradiol and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives can impair glucose tolerance and reduce the effect of antidiabetic therapy. Lixisenatide slows gastric emptying and may also reduce the absorption of oral contraceptives.
What this interaction means in plain words
Ethinylestradiol and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogens cause pharmacodynamic antagonism by reducing insulin sensitivity, and lixisenatide delays gastric emptying, lowering oral contraceptive absorption.
What to do
Take the oral contraceptive at least 1 hour before or 11 hours after lixisenatide. Monitor blood glucose and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Ethinylestradiol with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Ethinylestradiol and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogen-containing contraceptives can impair glucose tolerance and reduce the effect of antidiabetic therapy. Lixisenatide slows gastric emptying and may also reduce the absorption of oral contraceptives.
How serious is the interaction between Ethinylestradiol and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least 1 hour before or 11 hours after lixisenatide. Monitor blood glucose and adjust antidiabetic therapy as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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