Drug interactions
Ethinylestradiol + Nilotinib
Severity: Minor
Ethinylestradiol and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is a weak CYP3A4 inhibitor and may slightly raise nilotinib concentrations. Because nilotinib prolongs the QT interval in an exposure-related manner, higher levels are undesirable. The effect is probably small.
What this interaction means in plain words
Ethinylestradiol and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ethinylestradiol weakly inhibits CYP3A4, the main enzyme metabolizing nilotinib.
What to do
Obtain a baseline ECG and monitor the QTc periodically, and keep potassium and magnesium within normal range. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Nilotinib?
MediHelp rates the interaction as minor. Ethinylestradiol and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol is a weak CYP3A4 inhibitor and may slightly raise nilotinib concentrations. Because nilotinib prolongs the QT interval in an exposure-related manner, higher levels are undesirable. The effect is probably small.
How serious is the interaction between Ethinylestradiol and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc periodically, and keep potassium and magnesium within normal range. No dose change is usually needed.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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