Drug interactions
Ethinylestradiol + Rasagiline
Severity: Moderate
Ethinylestradiol and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol inhibits CYP1A2, which is the main route of rasagiline clearance. This can raise rasagiline levels and increase adverse effects.
What this interaction means in plain words
Ethinylestradiol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2 by ethinylestradiol, reducing rasagiline metabolism.
What to do
Limit rasagiline to 0.5 mg daily when combined with CYP1A2 inhibitors as labeled, and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinylestradiol and Rasagiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Ethinylestradiol with Rasagiline?
MediHelp rates the interaction as moderate. Ethinylestradiol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinylestradiol inhibits CYP1A2, which is the main route of rasagiline clearance. This can raise rasagiline levels and increase adverse effects.
How serious is the interaction between Ethinylestradiol and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit rasagiline to 0.5 mg daily when combined with CYP1A2 inhibitors as labeled, and monitor for adverse effects.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
