Drug interactions
Ethinylestradiol + Ropinirole
Severity: Moderate
Ethinylestradiol and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing products can raise ropinirole plasma concentrations. A population analysis in patients on ropinirole found lower clearance in women taking estrogens, so adverse effects may be more pronounced.
What this interaction means in plain words
Ethinylestradiol and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinylestradiol is thought to inhibit CYP1A2-mediated metabolism of ropinirole, reducing its clearance.
What to do
Adjust the ropinirole dose to clinical response when estrogen therapy is started or stopped. Watch for somnolence, nausea and orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Ethinylestradiol with Ropinirole?
MediHelp rates the interaction as moderate. Ethinylestradiol and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogen-containing products can raise ropinirole plasma concentrations. A population analysis in patients on ropinirole found lower clearance in women taking estrogens, so adverse effects may be more pronounced.
How serious is the interaction between Ethinylestradiol and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust the ropinirole dose to clinical response when estrogen therapy is started or stopped. Watch for somnolence, nausea and orthostatic hypotension.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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