Drug interactions
Ethinylestradiol + Tolterodine
Severity: Minor
Ethinylestradiol and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is a weak CYP3A4 inhibitor, so it could slightly raise tolterodine levels. Tolterodine is mainly cleared via CYP2D6, so any rise is small and rarely significant. No dose change is generally needed.
What this interaction means in plain words
Ethinylestradiol and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated tolterodine metabolism by ethinylestradiol.
What to do
No routine action. Be aware of increased anticholinergic effects if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Ethinylestradiol with Tolterodine?
MediHelp rates the interaction as minor. Ethinylestradiol and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol is a weak CYP3A4 inhibitor, so it could slightly raise tolterodine levels. Tolterodine is mainly cleared via CYP2D6, so any rise is small and rarely significant. No dose change is generally needed.
How serious is the interaction between Ethinylestradiol and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action. Be aware of increased anticholinergic effects if they emerge.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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