Drug interactions
Ethiodized oil + Glyburide-metformin
Severity: Major
Ethiodized oil and Glyburide-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, which can reduce metformin elimination and precipitate lactic acidosis. Risk is greater with impaired renal function or intra-arterial administration. Ethiodized oil is used in lymphography and hepatic chemoembolization, where systemic exposure and renal risk may be present.
What this interaction means in plain words
Ethiodized oil and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-associated kidney injury reduces renal clearance of metformin, leading to accumulation and lactic acidosis.
What to do
Hold metformin at the time of the procedure in patients with eGFR below 30, liver disease, or intra-arterial administration. Restart after 48 hours only once renal function is confirmed stable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Ethiodized oil with Glyburide-metformin?
MediHelp rates the interaction as major. Ethiodized oil and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, which can reduce metformin elimination and precipitate lactic acidosis. Risk is greater with impaired renal function or intra-arterial administration. Ethiodized oil is used in lymphography and hepatic chemoembolization, where systemic exposure and renal risk may be present.
How serious is the interaction between Ethiodized oil and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of the procedure in patients with eGFR below 30, liver disease, or intra-arterial administration. Restart after 48 hours only once renal function is confirmed stable.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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