Drug interactions
Ethosuximide + Givinostat
Severity: Minor
Ethosuximide and Givinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak CYP3A4 inhibitor and may modestly raise ethosuximide levels. The effect is likely small but could matter with higher ethosuximide doses.
What this interaction means in plain words
Ethosuximide and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethosuximide belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP3A4 reduces ethosuximide clearance.
What to do
Monitor for ethosuximide adverse effects such as sedation and nausea. Check levels only if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Ethosuximide with Givinostat?
MediHelp rates the interaction as minor. Ethosuximide and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak CYP3A4 inhibitor and may modestly raise ethosuximide levels. The effect is likely small but could matter with higher ethosuximide doses.
How serious is the interaction between Ethosuximide and Givinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide adverse effects such as sedation and nausea. Check levels only if toxicity is suspected.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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