Drug interactions
Ethosuximide + Glycerol phenylbutyrate
Severity: Minor
Ethosuximide and Glycerol phenylbutyrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycerol phenylbutyrate is a weak CYP3A4 inducer and could slightly lower ethosuximide levels. The clinical effect is probably small.
What this interaction means in plain words
Ethosuximide and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethosuximide belongs to Central Nervous System; Glycerol phenylbutyrate belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction increases ethosuximide metabolism.
What to do
Monitor seizure control after starting or stopping glycerol phenylbutyrate. Adjust the ethosuximide dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
- Fludrocortisone + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Ethosuximide with Glycerol phenylbutyrate?
MediHelp rates the interaction as minor. Ethosuximide and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycerol phenylbutyrate is a weak CYP3A4 inducer and could slightly lower ethosuximide levels. The clinical effect is probably small.
How serious is the interaction between Ethosuximide and Glycerol phenylbutyrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control after starting or stopping glycerol phenylbutyrate. Adjust the ethosuximide dose if control worsens.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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