Drug interactions
Ethotoin + Ketoconazole
Severity: Minor
Ethotoin and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is not a recognized inhibitor of the enzymes that clear ethotoin, and the effect is poorly documented. Any increase in ethotoin levels is theoretical.
What this interaction means in plain words
Ethotoin and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not established; the predicted effect is based on assumed CYP2C9 inhibition, which is weak for ketoconazole.
What to do
Monitor for signs of ethotoin toxicity such as ataxia, nystagmus or sedation. Measure levels if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ethotoin with Ketoconazole?
MediHelp rates the interaction as minor. Ethotoin and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole is not a recognized inhibitor of the enzymes that clear ethotoin, and the effect is poorly documented. Any increase in ethotoin levels is theoretical.
How serious is the interaction between Ethotoin and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of ethotoin toxicity such as ataxia, nystagmus or sedation. Measure levels if symptoms occur.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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