Drug interactions
Etoposide + Istradefylline
Severity: Minor
Etoposide and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline weakly inhibits CYP3A4 and may increase exposure to etoposide. The effect is likely small at 20 mg daily.
What this interaction means in plain words
Etoposide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etoposide belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition at higher doses slightly reduces etoposide clearance.
What to do
Monitor blood counts routinely; consider etoposide dose reduction only if toxicity occurs with istradefylline 40 mg daily.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Etoposide with Istradefylline?
MediHelp rates the interaction as minor. Etoposide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline weakly inhibits CYP3A4 and may increase exposure to etoposide. The effect is likely small at 20 mg daily.
How serious is the interaction between Etoposide and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts routinely; consider etoposide dose reduction only if toxicity occurs with istradefylline 40 mg daily.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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