Drug interactions
Etoposide + Larotrectinib
Severity: Minor
Etoposide and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a substrate of CYP3A4 and has only weak inhibitory effects on it. A clinically meaningful rise in etoposide exposure is not established and appears unlikely.
What this interaction means in plain words
Etoposide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etoposide belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by larotrectinib may slightly reduce etoposide clearance.
What to do
No dose adjustment is needed; monitor blood counts as routinely done during etoposide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Etoposide with Larotrectinib?
MediHelp rates the interaction as minor. Etoposide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a substrate of CYP3A4 and has only weak inhibitory effects on it. A clinically meaningful rise in etoposide exposure is not established and appears unlikely.
How serious is the interaction between Etoposide and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood counts as routinely done during etoposide therapy.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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