Drug interactions
Etoposide + Palifermin
Severity: Moderate
Etoposide and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to cytotoxic chemotherapy has been associated with more severe and longer-lasting oral mucositis. This offsets its intended protective effect.
What this interaction means in plain words
Etoposide and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Stimulated mucosal epithelial proliferation increases sensitivity to cytotoxic damage.
What to do
Do not give palifermin within 24 hours before, during or after etoposide. Monitor for mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Palifermin
Frequently asked questions
Can I take Etoposide with Palifermin?
MediHelp rates the interaction as moderate. Etoposide and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given close to cytotoxic chemotherapy has been associated with more severe and longer-lasting oral mucositis. This offsets its intended protective effect.
How serious is the interaction between Etoposide and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during or after etoposide. Monitor for mucositis.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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