Drug interactions
Etoposide + Sotorasib
Severity: Moderate
Etoposide and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor in vitro and clinically, so it may raise etoposide exposure rather than lower it. Higher etoposide levels could increase myelosuppression, mucositis and gastrointestinal toxicity.
What this interaction means in plain words
Etoposide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may inhibit P-glycoprotein-mediated efflux of etoposide, increasing its systemic exposure.
What to do
Monitor blood counts closely and watch for etoposide toxicity if the combination is needed. Consider reducing the etoposide dose if significant myelosuppression develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Etoposide with Sotorasib?
MediHelp rates the interaction as moderate. Etoposide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-glycoprotein inhibitor in vitro and clinically, so it may raise etoposide exposure rather than lower it. Higher etoposide levels could increase myelosuppression, mucositis and gastrointestinal toxicity.
How serious is the interaction between Etoposide and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and watch for etoposide toxicity if the combination is needed. Consider reducing the etoposide dose if significant myelosuppression develops.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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