Drug interactions
Etoposide + Trastuzumab
Severity: Moderate
Etoposide and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy such as etoposide is associated with a higher incidence of neutropenia and febrile neutropenia. This raises the risk of serious infection.
What this interaction means in plain words
Etoposide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression, with trastuzumab increasing the neutropenic effect of cytotoxic chemotherapy.
What to do
Monitor neutrophil counts regularly and give supportive care such as G-CSF or dose modification according to protocol if neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Etoposide with Trastuzumab?
MediHelp rates the interaction as moderate. Etoposide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy such as etoposide is associated with a higher incidence of neutropenia and febrile neutropenia. This raises the risk of serious infection.
How serious is the interaction between Etoposide and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts regularly and give supportive care such as G-CSF or dose modification according to protocol if neutropenia occurs.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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