Drug interactions
Etrasimod + Glimepiride-pioglitazone
Severity: Minor
Etrasimod and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is cleared by CYP2C8, CYP2C9 and CYP3A4. Pioglitazone is a CYP2C8 substrate and only a weak inhibitor, so the risk is mainly relevant in CYP2C9 poor metabolizers. Increased etrasimod exposure could enhance bradycardia and other adverse effects.
What this interaction means in plain words
Etrasimod and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etrasimod belongs to Gastrointestinal Tract; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Possible weak CYP2C8 inhibition by pioglitazone, reducing etrasimod clearance.
What to do
No routine adjustment is needed. Monitor heart rate after etrasimod initiation, especially in known CYP2C9 poor metabolizers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Etrasimod and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etrasimod is cleared by CYP2C8, CYP2C9 and CYP3A4. Pioglitazone is a CYP2C8 substrate and only a weak inhibitor, so the risk is mainly relevant in CYP2C9 poor metabolizers. Increased etrasimod exposure could enhance bradycardia and other adverse effects.
How serious is the interaction between Etrasimod and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor heart rate after etrasimod initiation, especially in known CYP2C9 poor metabolizers.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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