Drug interactions
Etrasimod + Pimozide
Severity: Major
Etrasimod and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can slow heart rate and delay AV conduction on initiation. With pimozide, a strongly QT-prolonging drug, bradycardia may raise the risk of torsades de pointes.
What this interaction means in plain words
Etrasimod and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Additive effects of bradycardia from S1P receptor modulation and QT prolongation from pimozide.
What to do
Avoid starting etrasimod in patients taking pimozide where possible, or obtain cardiology advice and an ECG before starting. Monitor heart rate and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Pimozide?
MediHelp rates the interaction as major. Etrasimod and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod can slow heart rate and delay AV conduction on initiation. With pimozide, a strongly QT-prolonging drug, bradycardia may raise the risk of torsades de pointes.
How serious is the interaction between Etrasimod and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting etrasimod in patients taking pimozide where possible, or obtain cardiology advice and an ECG before starting. Monitor heart rate and QTc.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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