Drug interactions
Etrasimod + Thioguanine
Severity: Major
Etrasimod and Thioguanine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes and thioguanine is myelosuppressive and immunosuppressive. Together they may cause additive immunosuppression and serious infection, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Thioguanine belongs to Oncology.
Why it happens
Additive immunosuppression: S1P receptor modulation reducing circulating lymphocytes plus antimetabolite myelosuppression.
What to do
Avoid the combination and allow an adequate interval after stopping etrasimod. If unavoidable, monitor blood counts and for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioguanine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Thioguanine?
MediHelp rates the interaction as major. Etrasimod and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes and thioguanine is myelosuppressive and immunosuppressive. Together they may cause additive immunosuppression and serious infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Thioguanine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow an adequate interval after stopping etrasimod. If unavoidable, monitor blood counts and for infection.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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