Drug interactions
Eucalyptus + Ketoconazole
Severity: Minor
Eucalyptus and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eucalyptus oil is metabolized in part by CYP3A4 and ketoconazole could increase its levels. Evidence of clinical significance is minimal and this is chiefly theoretical.
What this interaction means in plain words
Eucalyptus and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ketoconazole inhibition of CYP3A4 may reduce metabolism of eucalyptus constituents.
What to do
No specific action is needed beyond awareness. Avoid ingesting eucalyptus oil, which is toxic in overdose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Eucalyptus with Ketoconazole?
MediHelp rates the interaction as minor. Eucalyptus and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eucalyptus oil is metabolized in part by CYP3A4 and ketoconazole could increase its levels. Evidence of clinical significance is minimal and this is chiefly theoretical.
How serious is the interaction between Eucalyptus and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond awareness. Avoid ingesting eucalyptus oil, which is toxic in overdose.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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