Drug interactions
Exemestane + Istradefylline
Severity: Minor
Exemestane and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which could modestly increase exemestane levels. The effect is not seen at 20 mg daily, and exemestane has a wide safety margin.
What this interaction means in plain words
Exemestane and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Exemestane belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent inhibition of CYP3A4 by istradefylline.
What to do
No dose change is usually needed; monitor for exemestane adverse effects if istradefylline 40 mg is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exemestane
Other interactions of Istradefylline
Frequently asked questions
Can I take Exemestane with Istradefylline?
MediHelp rates the interaction as minor. Exemestane and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which could modestly increase exemestane levels. The effect is not seen at 20 mg daily, and exemestane has a wide safety margin.
How serious is the interaction between Exemestane and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for exemestane adverse effects if istradefylline 40 mg is used.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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