Drug interactions
Exemestane + Ivosidenib
Severity: Moderate
Exemestane and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower exemestane concentrations. Reduced exposure could weaken estrogen suppression and compromise cancer control.
What this interaction means in plain words
Exemestane and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction by ivosidenib increases exemestane metabolism.
What to do
Monitor for reduced exemestane efficacy and consider an alternative endocrine agent such as anastrozole or letrozole, which are less dependent on CYP3A4. Exemestane labeling suggests a higher dose with strong CYP3A4 inducers, which may be considered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exemestane
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Exemestane with Ivosidenib?
MediHelp rates the interaction as moderate. Exemestane and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower exemestane concentrations. Reduced exposure could weaken estrogen suppression and compromise cancer control.
How serious is the interaction between Exemestane and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced exemestane efficacy and consider an alternative endocrine agent such as anastrozole or letrozole, which are less dependent on CYP3A4. Exemestane labeling suggests a higher dose with strong CYP3A4 inducers, which may be considered.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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