Drug interactions
Exemestane + Oxcarbazepine
Severity: Moderate
Exemestane and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce exemestane concentrations and thus estrogen suppression. Labeling advises a higher exemestane dose with potent CYP3A4 inducers.
What this interaction means in plain words
Exemestane and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, which metabolizes exemestane.
What to do
Consider an alternative anticonvulsant. If it cannot be avoided, monitor efficacy and consider exemestane 50 mg daily after a meal as labeled for inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Exemestane
Frequently asked questions
Can I take Exemestane with Oxcarbazepine?
MediHelp rates the interaction as moderate. Exemestane and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce exemestane concentrations and thus estrogen suppression. Labeling advises a higher exemestane dose with potent CYP3A4 inducers.
How serious is the interaction between Exemestane and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative anticonvulsant. If it cannot be avoided, monitor efficacy and consider exemestane 50 mg daily after a meal as labeled for inducers.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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