Drug interactions
Exenatide + Lisinopril
Severity: Minor
Exenatide and Lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally enhance glucose lowering by antidiabetic drugs. With exenatide this may slightly raise hypoglycemia risk, mainly when sulfonylureas or insulin are also used.
What this interaction means in plain words
Exenatide and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Exenatide belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
ACE inhibition may enhance insulin sensitivity, adding to exenatide's glucose-lowering effect.
What to do
Monitor blood glucose during the first weeks after starting or stopping lisinopril. Lower the dose of concurrent sulfonylurea or insulin if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Exenatide with Lisinopril?
MediHelp rates the interaction as minor. Exenatide and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and occasionally enhance glucose lowering by antidiabetic drugs. With exenatide this may slightly raise hypoglycemia risk, mainly when sulfonylureas or insulin are also used.
How serious is the interaction between Exenatide and Lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the first weeks after starting or stopping lisinopril. Lower the dose of concurrent sulfonylurea or insulin if hypoglycemia occurs.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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