Drug interactions
Exenatide + Prednisolone
Severity: Moderate
Exenatide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids raise blood glucose and can offset the glycemic benefit of exenatide. Hyperglycemia may appear soon after starting or increasing the steroid dose.
What this interaction means in plain words
Exenatide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exenatide belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoids increase hepatic gluconeogenesis and cause peripheral insulin resistance.
What to do
Monitor blood glucose more frequently during corticosteroid courses and increase antidiabetic therapy if needed. Reassess doses when the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Exenatide with Prednisolone?
MediHelp rates the interaction as moderate. Exenatide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids raise blood glucose and can offset the glycemic benefit of exenatide. Hyperglycemia may appear soon after starting or increasing the steroid dose.
How serious is the interaction between Exenatide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during corticosteroid courses and increase antidiabetic therapy if needed. Reassess doses when the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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