Drug interactions
Exenatide + Repaglinide
Severity: Moderate
Exenatide and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs stimulate insulin release, so combined use can increase the risk of hypoglycemia. Exenatide also slows gastric emptying, which may alter the timing of repaglinide's effect around meals.
What this interaction means in plain words
Exenatide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exenatide belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamics: exenatide enhances glucose-dependent insulin secretion and repaglinide closes pancreatic beta-cell potassium channels to release insulin.
What to do
Monitor blood glucose and counsel patients on hypoglycemia symptoms. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Exenatide with Repaglinide?
MediHelp rates the interaction as moderate. Exenatide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs stimulate insulin release, so combined use can increase the risk of hypoglycemia. Exenatide also slows gastric emptying, which may alter the timing of repaglinide's effect around meals.
How serious is the interaction between Exenatide and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and counsel patients on hypoglycemia symptoms. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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