Drug interactions
Exenatide injectable + Gliclazide
Severity: Moderate
Exenatide injectable and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide increases glucose-dependent insulin secretion and, combined with a sulfonylurea, raises the risk of hypoglycemia. This is documented in product labeling.
What this interaction means in plain words
Exenatide injectable and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
GLP-1 receptor agonism and sulfonylurea-induced insulin release are additive in stimulating insulin secretion.
What to do
Consider lowering the gliclazide dose when starting exenatide and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Exenatide injectable and Gliclazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Frequently asked questions
Can I take Exenatide injectable with Gliclazide?
MediHelp rates the interaction as moderate. Exenatide injectable and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide increases glucose-dependent insulin secretion and, combined with a sulfonylurea, raises the risk of hypoglycemia. This is documented in product labeling.
How serious is the interaction between Exenatide injectable and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the gliclazide dose when starting exenatide and monitor blood glucose.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
