Drug interactions
Exenatide injectable + Insulin isophane protamine human
Severity: Moderate
Exenatide injectable and Insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide combined with insulin gives additive glucose lowering and a greater likelihood of hypoglycemia. Exenatide also slows gastric emptying, which may alter glycemic patterns.
What this interaction means in plain words
Exenatide injectable and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of a GLP-1 receptor agonist (glucose-dependent insulin secretion, glucagon suppression) with exogenous insulin.
What to do
Monitor blood glucose frequently when starting exenatide and consider reducing the insulin dose to prevent hypoglycemia. Adjust doses according to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Frequently asked questions
Can I take Exenatide injectable with Insulin isophane protamine human?
MediHelp rates the interaction as moderate. Exenatide injectable and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide combined with insulin gives additive glucose lowering and a greater likelihood of hypoglycemia. Exenatide also slows gastric emptying, which may alter glycemic patterns.
How serious is the interaction between Exenatide injectable and Insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting exenatide and consider reducing the insulin dose to prevent hypoglycemia. Adjust doses according to glucose readings.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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