Drug interactions
Insulin isophane protamine human + Rosiglitazone
Severity: Major
Insulin isophane protamine human and Rosiglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone with insulin adds to glucose lowering and increases hypoglycemia risk. The combination raises the risk of fluid retention, heart failure and possibly ischemic cardiac events, and labeling advises against it in many regions.
What this interaction means in plain words
Insulin isophane protamine human and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin isophane protamine human belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Insulin sensitization adds to insulin's action, and thiazolidinedione-related fluid retention is amplified by insulin.
What to do
Avoid the combination where possible and choose an alternative agent. If used, monitor for edema, weight gain and heart failure and reduce the insulin dose for hypoglycemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
- Aspirin + Insulin isophane protamine human Moderate
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Insulin isophane protamine human with Rosiglitazone?
MediHelp rates the interaction as major. Insulin isophane protamine human and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone with insulin adds to glucose lowering and increases hypoglycemia risk. The combination raises the risk of fluid retention, heart failure and possibly ischemic cardiac events, and labeling advises against it in many regions.
How serious is the interaction between Insulin isophane protamine human and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative agent. If used, monitor for edema, weight gain and heart failure and reduce the insulin dose for hypoglycemia.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Acarbose. The full list is on the Insulin isophane protamine human page.
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