Drug interactions
Exenatide injectable + Prednisolone
Severity: Moderate
Exenatide injectable and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisolone raises blood glucose and can counteract the glucose-lowering effect of exenatide. Hyperglycemia can worsen during high-dose or prolonged steroid therapy.
What this interaction means in plain words
Exenatide injectable and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: corticosteroids increase gluconeogenesis and insulin resistance, opposing GLP-1 receptor agonist action.
What to do
Monitor blood glucose more closely when starting, changing or stopping prednisolone. Adjust the antidiabetic regimen as needed and reduce it when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Exenatide injectable with Prednisolone?
MediHelp rates the interaction as moderate. Exenatide injectable and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisolone raises blood glucose and can counteract the glucose-lowering effect of exenatide. Hyperglycemia can worsen during high-dose or prolonged steroid therapy.
How serious is the interaction between Exenatide injectable and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when starting, changing or stopping prednisolone. Adjust the antidiabetic regimen as needed and reduce it when the steroid is tapered.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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