Drug interactions
Exenatide injectable + Repaglinide
Severity: Moderate
Exenatide injectable and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide enhances glucose-dependent insulin secretion and combined with an insulin secretagogue such as repaglinide raises the risk of hypoglycemia.
What this interaction means in plain words
Exenatide injectable and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on insulin secretion.
What to do
Monitor blood glucose when starting exenatide and consider lowering the repaglinide dose. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Exenatide injectable with Repaglinide?
MediHelp rates the interaction as moderate. Exenatide injectable and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide enhances glucose-dependent insulin secretion and combined with an insulin secretagogue such as repaglinide raises the risk of hypoglycemia.
How serious is the interaction between Exenatide injectable and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting exenatide and consider lowering the repaglinide dose. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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