Drug interactions
Ezogabine + Lumefantrine
Severity: Moderate
Ezogabine and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, and ezogabine has a smaller QT effect of its own. Together they may increase the likelihood of clinically significant QT prolongation and arrhythmia.
What this interaction means in plain words
Ezogabine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of ventricular repolarization.
What to do
Obtain an ECG before and during treatment when the combination cannot be avoided. Correct hypokalemia and hypomagnesemia and consider an alternative antimalarial or anticonvulsant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Lumefantrine?
MediHelp rates the interaction as moderate. Ezogabine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, and ezogabine has a smaller QT effect of its own. Together they may increase the likelihood of clinically significant QT prolongation and arrhythmia.
How serious is the interaction between Ezogabine and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before and during treatment when the combination cannot be avoided. Correct hypokalemia and hypomagnesemia and consider an alternative antimalarial or anticonvulsant in patients with other QT risk factors.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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