Drug interactions
Ezogabine + Romidepsin
Severity: Moderate
Ezogabine and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT prolongation and ECG changes, and ezogabine has a modest QT effect. Together they may increase the risk of clinically significant arrhythmia.
What this interaction means in plain words
Ezogabine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Check baseline and periodic ECGs and maintain normal potassium and magnesium. Consider an alternative if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Romidepsin?
MediHelp rates the interaction as moderate. Ezogabine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause QT prolongation and ECG changes, and ezogabine has a modest QT effect. Together they may increase the risk of clinically significant arrhythmia.
How serious is the interaction between Ezogabine and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and maintain normal potassium and magnesium. Consider an alternative if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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