Drug interactions
Ezogabine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Ezogabine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate, particularly at higher systemic exposure. With ezogabine, which may prolong the QT interval, there is a potential for additive QTc effects, though inhaled systemic exposure is low.
What this interaction means in plain words
Ezogabine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive effects on QTc; beta-agonist cardiovascular effects may be potentiated by QT-prolonging drugs.
What to do
Monitor for palpitations, syncope and ECG changes, especially in patients with cardiac disease or electrolyte abnormalities. Keep inhaler doses at the labeled amount.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Ezogabine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate, particularly at higher systemic exposure. With ezogabine, which may prolong the QT interval, there is a potential for additive QTc effects, though inhaled systemic exposure is low.
How serious is the interaction between Ezogabine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations, syncope and ECG changes, especially in patients with cardiac disease or electrolyte abnormalities. Keep inhaler doses at the labeled amount.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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